Target
Alpha-galactosidase A
Ligand
BDBM50204610
Substrate
n/a
Meas. Tech.
ChEMBL_1627785 (CHEMBL3870370)
pH
7±n/a
IC50
10600±n/a nM
Comments
extracted
Citation
 Cheng, WCWang, JHLi, HYLu, SJHu, JMYun, WYChiu, CHYang, WBChien, YHHwu, WL Bioevaluation of sixteen ADMDP stereoisomers toward alpha-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency. Eur J Med Chem 123:14-20 (2016) [PubMed]  Article 
Target
Name:
Alpha-galactosidase A
Synonyms:
AGAL_HUMAN | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A) | GLA | INN=Agalsidase | Melibiase
Type:
Protein
Mol. Mass.:
48760.21
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
  
Inhibitor
Name:
BDBM50204610
Synonyms:
CHEMBL3908900
Type:
Small organic molecule
Emp. Form.:
C6H14N2O3
Mol. Mass.:
162.187
SMILES:
NC[C@@H]1N[C@H](CO)[C@H](O)[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: