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Target
D(2) dopamine receptor
Ligand
BDBM50207108
Substrate
n/a
Meas. Tech.
ChEMBL_1630049 (CHEMBL3872755)
Ki
1.9±n/a nM
Citation
 Chen, XW; Sun, YY; Fu, L; Li, JQ Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. Eur J Med Chem 123:332-353 (2016) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50207108
Synonyms:
CHEMBL3920432
Type:
Small organic molecule
Emp. Form.:
C22H34N4O2S2
Mol. Mass.:
450.661
SMILES:
CCCS(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1 |r,wU:10.10,wD:7.6,(41.02,-21.07,;39.48,-21.06,;38.71,-22.4,;37.17,-22.39,;37.16,-23.93,;35.83,-23.16,;36.4,-21.06,;34.86,-21.06,;34.09,-19.73,;32.55,-19.74,;31.79,-21.07,;30.25,-21.07,;29.47,-19.74,;27.93,-19.74,;27.16,-18.41,;25.62,-18.41,;24.86,-19.74,;25.63,-21.07,;27.17,-21.07,;23.32,-19.74,;22.42,-20.99,;20.95,-20.51,;20.95,-18.97,;19.8,-17.94,;20.13,-16.44,;21.59,-15.96,;22.73,-16.99,;22.41,-18.49,;32.55,-22.4,;34.09,-22.4,)|
Structure:
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