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Target
D(2) dopamine receptor
Ligand
BDBM50207152
Substrate
n/a
Meas. Tech.
ChEMBL_1630049 (CHEMBL3872755)
Ki
0.510000±n/a nM
Citation
 Chen, XW; Sun, YY; Fu, L; Li, JQ Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. Eur J Med Chem 123:332-353 (2016) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50207152
Synonyms:
CHEMBL3971907
Type:
Small organic molecule
Emp. Form.:
C23H35N5OS
Mol. Mass.:
429.622
SMILES:
CCN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1 |r,wU:7.6,wD:10.10,(10.36,-14.68,;9.54,-15.96,;10.26,-17.34,;9.38,-18.63,;11.75,-17.4,;12.46,-18.78,;12.51,-16.06,;14.05,-16.06,;14.82,-14.73,;16.36,-14.73,;17.13,-16.06,;18.67,-16.06,;19.44,-14.73,;20.98,-14.73,;21.75,-13.39,;23.29,-13.39,;24.05,-14.73,;23.29,-16.06,;21.75,-16.06,;25.59,-14.73,;26.52,-16.01,;28.01,-15.5,;28.01,-13.96,;29.07,-12.93,;28.77,-11.44,;27.34,-10.98,;26.21,-12.01,;26.52,-13.49,;16.36,-17.4,;14.82,-17.4,)|
Structure:
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