Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50211082
Substrate
n/a
Meas. Tech.
ChEMBL_1636003 (CHEMBL3878901)
Ki
0.920000±n/a nM
Citation
 Varano, F; Catarzi, D; Vincenzi, F; Betti, M; Falsini, M; Ravani, A; Borea, PA; Colotta, V; Varani, K Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A J Med Chem 59:10564-10576 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50211082
Synonyms:
CHEMBL3907658
Type:
Small organic molecule
Emp. Form.:
C18H17N5O2S
Mol. Mass.:
367.425
SMILES:
COc1cccc(CCNc2nc(N)c3nc(sc3n2)-c2ccco2)c1
Structure:
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