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Target
Endoplasmic reticulum aminopeptidase 2
Ligand
BDBM50400206
Substrate
n/a
Meas. Tech.
ChEMBL_1636857 (CHEMBL3879755)
IC50
>100000±n/a nM
Citation
 Mpakali, A; Giastas, P; Deprez-Poulain, R; Papakyriakou, A; Koumantou, D; Gealageas, R; Tsoukalidou, S; Vourloumis, D; Mavridis, IM; Stratikos, E; Saridakis, E Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. ACS Med Chem Lett 8:333-337 (2017) [PubMed]  Article 
Target
Name:
Endoplasmic reticulum aminopeptidase 2
Synonyms:
Aminopeptidase | ERAP2 | ERAP2_HUMAN | LRAP
Type:
PROTEIN
Mol. Mass.:
110463.90
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473169
Residue:
960
Sequence:
MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT
  
Inhibitor
Name:
BDBM50400206
Synonyms:
CHEMBL2180993
Type:
Small organic molecule
Emp. Form.:
C17H17FN2O3
Mol. Mass.:
316.3269
SMILES:
ONC(=O)C(Cc1ccc(F)cc1)C(=O)NCc1ccccc1
Structure:
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