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Target
Corticotropin-releasing factor receptor 1/2
Ligand
BDBM50220479
Substrate
n/a
Meas. Tech.
ChEMBL_50968 (CHEMBL666049)
Ki
0.500000±n/a nM
Citation
 Arvanitis, AG; Rescinito, JT; Arnold, CR; Wilde, RG; Cain, GA; Sun, JH; Yan, JS; Teleha, CA; Fitzgerald, LW; McElroy, J; Zaczek, R; Hartig, PR; Grossman, S; Arneric, SP; Gilligan, PJ; Olson, RE; Robertson, DW Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands. Bioorg Med Chem Lett 13:125-8 (2003) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1/2
Synonyms:
Corticotropin releasing factor receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 217368
Components:
This complex has 2 components.
Component 1
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47870.75
Organism:
Rattus norvegicus (rat)
Description:
Receptor binding assays were performed using rat cortex homogenate.
Residue:
415
Sequence:
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Component 2
Name:
Corticotropin-releasing factor receptor 2
Synonyms:
CRF-R-2 | CRF-R2 | CRF2 Beta | CRFR-2 | CRFR2_RAT | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47697.09
Organism:
RAT
Description:
CRF2 Beta 0 RAT::P47866
Residue:
411
Sequence:
MDAALLLSLLEANCSLALAEELLLDGWGEPPDPEGPYSYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIINYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNITWFLLQLIDHEVHEGNEVWCRCVTTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIVAWAVGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRSALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
  
Inhibitor
Name:
BDBM50220479
Synonyms:
CHEMBL23342
Type:
Small organic molecule
Emp. Form.:
C19H21Cl2N3
Mol. Mass.:
362.296
SMILES:
CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)cc1Cl
Structure:
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