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Target
Mitogen-activated protein kinase 13
Ligand
BDBM50222109
Substrate
n/a
Meas. Tech.
ChEMBL_124320 (CHEMBL732628)
IC50
2.0±n/a nM
Citation
 Natarajan, SR; Wisnoski, DD; Singh, SB; Stelmach, JE; O'Neill, EA; Schwartz, CD; Thompson, CM; Fitzgerald, CE; O'Keefe, SJ; Kumar, S; Hop, CE; Zaller, DM; Schmatz, DM; Doherty, JB p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold. Bioorg Med Chem Lett 13:273-6 (2003) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 13
Synonyms:
MAP kinase 13 | MAP kinase p38 delta | MAPK 13 | MK13_MOUSE | Mapk13 | Mitogen-activated protein kinase 13 | Mitogen-activated protein kinase p38 delta | Serk4 | Stress-activated protein kinase 4
Type:
PROTEIN
Mol. Mass.:
42081.17
Organism:
Mus musculus
Description:
ChEMBL_105000
Residue:
366
Sequence:
MSLTRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMGMEFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFFEPFRDPEEETEAQQPFDDALEHEKLSVDEWKQHIYKEISNFSPIARKDSRRRSGMKLQ
  
Inhibitor
Name:
BDBM50222109
Synonyms:
CHEMBL93059
Type:
Small organic molecule
Emp. Form.:
C23H19Cl2F2N5OS
Mol. Mass.:
522.398
SMILES:
Fc1ccc(Sc2nc3CNC(=O)N(c3cc2N2CCNCC2)c2c(Cl)cccc2Cl)c(F)c1
Structure:
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