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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50228826
Substrate
n/a
Meas. Tech.
ChEMBL_40449 (CHEMBL652387)
IC50
>100±n/a nM
Citation
 Saccomano, NA; Vinick, FJ; Koe, BK; Nielsen, JA; Whalen, WM; Meltz, M; Phillips, D; Thadieo, PF; Jung, S; Chapin, DS Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones. J Med Chem 34:291-8 (1991) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50228826
Synonyms:
CHEMBL317379
Type:
Small organic molecule
Emp. Form.:
C21H28N2O3
Mol. Mass.:
356.4586
SMILES:
COc1ccc(cc1OC1C2CC3CC(C2)CC1C3)C1CNC(=O)N1C |TLB:15:10:18:14.16.13,15:14:9.10.11:18,8:9:12.11.18:14.16.15,8:9:18:14.16.13,THB:13:12:9:14.16.15,13:14:9:12.11.18,(16.59,-.52,;15.25,-1.29,;15.25,-2.83,;16.6,-3.6,;16.6,-5.14,;15.25,-5.91,;13.93,-5.14,;13.93,-3.6,;12.59,-4.36,;11.26,-3.59,;10.28,-4.79,;8.69,-3.89,;7.45,-4.12,;7.45,-5.66,;8.77,-6.43,;10.28,-6.33,;9.86,-5.34,;9.95,-3.8,;8.42,-2.92,;15.25,-7.45,;14.03,-8.37,;14.5,-9.83,;16.04,-9.83,;16.95,-11.08,;16.52,-8.37,;17.98,-7.89,)|
Structure:
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