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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50218545
Substrate
n/a
Meas. Tech.
ChEMBL_42949 (CHEMBL656314)
IC50
1900±n/a nM
Citation
 Lowe, JA; Archer, RL; Chapin, DS; Chen, JB; Helweg, D; Johnson, JL; Koe, BK; Lebel, LA; Moore, PF; Nielsen, JA Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase. J Med Chem 34:624-8 (1991) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50218545
Synonyms:
Nitraquazone
Type:
Small organic molecule
Emp. Form.:
C16H13N3O4
Mol. Mass.:
311.2921
SMILES:
CCn1c(=O)n(-c2cccc(c2)[N+]([O-])=O)c2ccccc2c1=O
Structure:
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