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TargetC5a anaphylatoxin chemotactic receptor
LigandBDBM55880
Substrate/Competitorn/a
Meas. Tech.ChEBML_41451
IC50 12±n/a nM
Citation Lanza, TJDurette, PLRollins, TSiciliano, SCianciarulo, DNKobayashi, SVCaldwell, CGSpringer, MSHagmann, WK Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding. J Med Chem35:252-8 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C5a anaphylatoxin chemotactic receptor
Name:C5a anaphylatoxin chemotactic receptor
Synonyms:C5a anaphylatoxin chemotactic receptor | C5a-R | C5aR | CD_antigen=CD88
Type:Enzyme
Mol. Mass.:39347.68
Organism:Homo sapiens (Human)
Description:P21730
Residue:350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
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BDBM55880
NameBDBM55880
Synonyms:(E)-N-(4-amino-2-methyl-6-quinolinyl)-3-(2-chlorophenyl)-2-propenamide | (E)-N-(4-amino-2-methyl-6-quinolyl)-3-(2-chlorophenyl)acrylamide | (E)-N-(4-amino-2-methylquinolin-6-yl)-3-(2-chlorophenyl)prop-2-enamide | (E)-N-(4-azanyl-2-methyl-quinolin-6-yl)-3-(2-chlorophenyl)prop-2-enamide | MLS000737665 | SMR000393832 | cid_5773323
TypeSmall organic molecule
Emp. Form.C19H16ClN3O
Mol. Mass.337.803
SMILESCc1cc(N)c2cc(NC(=O)\C=C\c3ccccc3Cl)ccc2n1
Structure
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n/a