Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50235259
Substrate
n/a
Meas. Tech.
ChEMBL_1655133 (CHEMBL4004499)
IC50
26±n/a nM
Citation
 Wolkenberg, SENolt, MBBilodeau, MTTrotter, BWManley, PJKett, NRNanda, KKWu, ZCato, MJKane, SAKiss, LSpencer, RHWang, JLynch, JJRegan, CPStump, GLLi, BWhite, RYeh, SDinsmore, CJLindsley, CWHartman, GD Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorg Med Chem Lett 27:1062-1069 (2017) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50235259
Synonyms:
CHEMBL4105245
Type:
Small organic molecule
Emp. Form.:
C23H17Cl2N3
Mol. Mass.:
406.307
SMILES:
Clc1ccccc1-c1ncccc1CC(c1cccnc1)c1cccnc1Cl
Structure:
Search PDB for entries with ligand similarity: