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TargetDopamine transporter
LigandBDBM50237600
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1661738
IC50 4300±n/a nM
Citation Tosh, DKJanowsky, AEshleman, AJWarnick, EGao, ZGChen, ZGizewski, EAuchampach, JASalvemini, DJacobson, KA Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. J Med Chem60:3109-3123 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine transporter
Name:Dopamine transporter
Synonyms:DA transporter | DAT | Sodium-dependent dopamine transporter | Solute carrier family 6 member 3
Type:Enzyme Catalytic Domain
Mol. Mass.:68809.06
Organism:MOUSE
Description:Dopamine Transporter SLC6A3 MOUSE::Q61327
Residue:619
Sequence:
MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEVQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDR
QLVDRGEVRQFTLRHWLLV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50237600
NameBDBM50237600
Synonyms:CHEMBL4071867
TypeSmall organic molecule
Emp. Form.C21H20ClN5O3S
Mol. Mass.457.933
SMILES[H][C@]12C[C@]1([C@@H](O)[C@@H](O)[C@@H]2n1cnc2c(NC)nc(cc12)C#Cc1ccc(Cl)s1)C(=O)NC |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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