Target
Casein kinase I isoform epsilon
Ligand
BDBM274683
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
6.56±n/a nM
Comments
extracted
Citation
 Velaparthi, UDarne, CPDodd, DSSampognaro, AJWittman, MDKumaravel, SMullick, DLiu, PRachamreddy, CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent  US9556179 Publication Date 1/31/2017 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM274683
Synonyms:
N-(6-(1-(2,2-dimethylpropyl)-4-(4- fluorophenyl)-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2-yl)-2- fluoroisonicotinamide | US9556179, Compound 258
Type:
Small organic molecule
Emp. Form.:
C26H23F2N7O
Mol. Mass.:
487.5039
SMILES:
CC(C)(C)Cn1cnc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1
Structure:
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