Ki Summary

Reaction Details

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Target

Melanocortin receptor 5

Ligand

BDBM82416

Substrate

n/a

>10000±n/a nM

Comments

PDSP_2959

Citation

Schiöth, HB; Muceniece, R; Wikberg, JE Characterisation of the melanocortin 4 receptor by radioligand binding. Pharmacol Toxicol 79:161-5 (1996) [PubMed] Article

More Info.:

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Target

Name:

Melanocortin receptor 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

36612.92

Organism:

Homo sapiens (Human)

Description:

P33032

Residue:

325

Sequence:

MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD

Inhibitor

Name:

BDBM82416

Synonyms:

Gamma3-MSH

Type:

Small organic molecule

Emp. Form.:

C126H188N44O37S

Mol. Mass.:

2943.179

SMILES:

CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CC(N)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)NCC(=O)N[C@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](C)C(=O)N[C@H](CCC(N)=O)C(O)=O |r,wU:64.66,86.90,42.43,8.8,112.117,134.139,146.151,158.163,189.195,199.204,wD:78.82,53.55,97.101,32.32,4.4,12.12,123.128,152.157,164.169,174.179,194.200,(-14.05,.99,;-14.79,2.35,;-14.03,3.65,;-14.77,5,;-14.01,6.33,;-14.74,7.71,;-16.26,7.73,;-17.05,6.43,;-17.04,9.09,;-18.56,9.11,;-19.32,10.42,;-18.57,11.81,;-20.87,10.42,;-21.62,11.76,;-21.65,9.02,;-20.87,7.69,;-21.62,6.34,;-20.84,5.03,;-19.27,5.05,;-18.54,3.73,;-18.56,6.43,;-19.33,7.69,;-16.24,10.41,;-17.02,11.76,;-14.7,10.37,;-12.42,6.34,;-11.64,7.66,;-11.63,5.05,;-10.09,5.12,;-9.33,3.79,;-10.05,2.47,;-7.8,3.75,;-7.06,2.39,;-7.8,1.04,;-7.06,-.28,;-5.54,-.43,;-5.13,-1.9,;-6.42,-2.71,;-7.65,-1.76,;-5.47,2.4,;-4.71,3.73,;-4.68,1.11,;-3.12,1.18,;-2.36,2.54,;-.86,2.59,;-.16,3.96,;1.39,3.98,;2.27,2.71,;1.55,1.33,;-.01,1.31,;-2.31,-.1,;-3.02,-1.45,;-.79,-.03,;.06,-1.28,;-.63,-2.68,;.27,-3.99,;-.44,-5.36,;.51,-6.64,;-.15,-7.99,;.77,-9.27,;-1.62,-8.21,;1.63,-1.23,;2.31,.16,;2.5,-2.47,;3.95,-2.35,;4.73,-.92,;6.15,-.69,;7.25,-1.9,;8.72,-1.33,;8.53,.26,;9.57,1.37,;9.12,2.85,;7.6,3.13,;6.56,2.06,;7.01,.55,;4.9,-3.56,;4.09,-5.13,;6.39,-3.25,;7.42,-4.37,;6.98,-5.86,;8.03,-6.98,;9.52,-6.64,;7.53,-8.52,;8.96,-4.04,;9.41,-2.59,;10,-5.13,;11.45,-4.77,;11.9,-3.27,;13.46,-2.92,;13.89,-1.45,;15.43,-1.18,;15.91,.29,;17.43,.59,;14.96,1.44,;12.56,-5.88,;12.13,-7.38,;14.05,-5.51,;15.12,-6.64,;14.7,-8.12,;15.76,-9.23,;17.28,-8.9,;18.37,-10.04,;17.92,-11.48,;16.4,-11.81,;15.32,-10.7,;16.6,-6.26,;17.04,-4.81,;17.64,-7.35,;19.13,-6.97,;20.17,-8.09,;19.73,-9.54,;21.67,-7.76,;22.76,-8.85,;22.36,-10.33,;23.69,-11.1,;23.29,-12.59,;24.63,-13.36,;24.63,-14.9,;23.29,-15.67,;25.96,-15.67,;24.25,-8.45,;24.64,-6.96,;25.58,-9.22,;26.91,-8.45,;26.91,-6.91,;28.25,-6.14,;28.25,-4.6,;29.58,-3.83,;29.58,-2.29,;28.49,-1.2,;30.67,-1.2,;28.25,-9.22,;27.85,-10.71,;29.73,-8.82,;31.07,-9.59,;31.07,-11.13,;29.98,-12.22,;28.49,-11.82,;29.98,-13.76,;32.4,-8.82,;32.4,-7.28,;33.73,-9.59,;35.07,-8.82,;36.4,-9.59,;36.4,-11.13,;37.74,-8.82,;39.07,-9.59,;39.07,-11.13,;37.98,-12.22,;40.4,-8.82,;40.4,-7.28,;41.74,-9.59,;43.07,-8.82,;43.07,-7.28,;41.98,-6.19,;44.4,-9.59,;44.4,-11.13,;45.74,-8.82,;47.07,-9.59,;47.07,-11.13,;45.98,-12.22,;48.41,-8.82,;48.41,-7.28,;49.74,-9.59,;51.07,-8.82,;51.07,-7.28,;49.98,-6.19,;52.41,-9.59,;52.41,-11.13,;53.74,-8.82,;55.07,-9.59,;56.41,-8.82,;56.41,-7.28,;57.74,-9.59,;59.07,-8.82,;59.07,-7.28,;57.99,-6.19,;60.41,-6.51,;60.41,-9.59,;60.41,-11.13,;61.74,-8.82,;63.08,-9.59,;64.41,-8.82,;64.41,-7.28,;65.74,-9.59,;67.08,-8.82,;68.41,-9.59,;68.41,-11.13,;69.74,-8.82,;71.08,-9.59,;71.08,-11.13,;72.17,-8.5,;72.17,-6.96,;73.5,-9.27,;74.59,-8.18,;74.59,-6.64,;75.92,-8.95,;75.92,-10.49,;77.26,-8.18,;78.59,-8.95,;78.59,-10.49,;79.92,-11.26,;79.92,-12.8,;78.84,-13.89,;81.26,-13.57,;79.92,-8.18,;81.26,-8.95,;79.92,-6.64,)|

Structure: