Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 2

Ligand

BDBM85375

Substrate

n/a

0.117±n/a nM

Comments

PDSP_7552

Citation

Sharma, P; Holmberg, SK; Eriksson, H; Beck-Sickinger, AG; Grundemar, L; Larhammar, D Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor. Regul Pept 0:23-8 (1998) [PubMed] Article

More Info.:

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Target

Name:

Neuropeptide Y receptor type 2

Synonyms:

NPY-Y2 | NPY2R | NPY2R_CAVPO | Neuropeptide Y receptor type 2

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42344.53

Organism:

GUINEA PIG

Description:

NPY-Y2 NPY2R GUINEA PIG::Q9Z2D5

Residue:

381

Sequence:

MGPIGTEADENQTVEEIKVEPYGPGHTTPRGELAPDPEPELIDSTKLTEVRVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTVTLTVIALDRHRCIVYHLDSKISKQNSFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISVSYVRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVFVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCQQRLDAIQSEVCVTGKAKTNVEVEKNHGAADSAEATNV

Inhibitor

Name:

BDBM85375

Synonyms:

NPY8-20, Ahx

Type:

Small organic molecule

Emp. Form.:

C135H208N40O36

Mol. Mass.:

2967.3424

SMILES:

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O

Structure: