Ki Summary

Reaction Details

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Target

Calcitonin gene-related peptide type 1 receptor

Ligand

BDBM85842

Substrate

n/a

499.9±n/a nM

Comments

PDSP_2308

Citation

Rorabaugh, BR; Scofield, MA; Smith, DD; Jeffries, WB; Abel, PW Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction. J Pharmacol Exp Ther 299:1086-94 (2001) [PubMed]

More Info.:

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Target

Name:

Calcitonin gene-related peptide type 1 receptor

Synonyms:

CALCRL | CALRL_PIG | CGRP | CGRPR

Type:

Enzyme Catalytic Domain

Mol. Mass.:

53657.10

Organism:

PIG

Description:

CGRP 0 PIG::Q8WN93

Residue:

462

Sequence:

MEKKYILYFLFLLPFFMILVIAETEEENPDDLIQLTVTRNKIMTAQYECYQKIMQDPIQQTEGIYCNRTWDGWLCWNDVAAGTESMQHCPDYFQDFDPSEKVTKICDQDGNWFRHPESNRTWTNYTQCNINTHEKVQTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVFQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAVARRLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILVHYQGLLVSTIYCFFNGEVQAILRRNWNQYKIQFGNSFSHSDALRSASYTVSTISDGAGYSHDYPSEHLNGKSIHDMENIVIKPEKLYD

Inhibitor

Name:

BDBM85842

Synonyms:

[Ala37]h alpha-CGRP8-37

Type:

Small organic molecule

Emp. Form.:

C133H226N44O38

Mol. Mass.:

3049.4895

SMILES:

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Structure: