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Target
Neuromedin-K receptor
Ligand
BDBM85083
Substrate
n/a
Ki
0.16±n/a nM
Comments
PDSP_1335
Citation
 Emonds-Alt, X; Proietto, V; Steinberg, R; Oury-Donat, F; Vigé, X; Vilain, P; Naline, E; Daoui, S; Advenier, C; Le Fur, G; Maffrand, JP; Soubrié, P; Pascal, M SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pharmacological characterization. J Pharmacol Exp Ther 303:1171-9 (2002) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
Neurokinin NK3 | TACR3 | Tachykinin receptor 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51187.68
Organism:
Gerbil
Description:
Q2YHR0
Residue:
454
Sequence:
MASVPTAESESWTDGAAGVGTQVGNLSSALGVTEWFALQAGNFSSALGVPVTSPTPSQARANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFIITAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPAKSSRKKKAVPRDPSTNGCARRDSKSASTTSSFISSPYTSVDEYS
  
Inhibitor
Name:
BDBM85083
Synonyms:
NKB [MePhe7]
Type:
Small organic molecule
Emp. Form.:
C56H81N13O14S2
Mol. Mass.:
1224.451
SMILES:
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(N)=O
Structure:
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