Reaction Details Report a problem with these data
Target
Glutathione S-transferase E2
Ligand
BDBM50186231
Substrate
n/a
Meas. Tech.
GST Inhibition Assay
pH
6.5±0
Temperature
303.15±0 K
IC50
1.4e+3±n/a nM
Citation
 Muleya, V; Hayeshi, R; Ranson, H; Abegaz, B; Bezabih, MT; Robert, M; Ngadjui, BT; Ngandeu, F; Mukanganyama, S Modulation of Anopheles gambiae Epsilon glutathione transferase activity by plant natural products in vitro. J Enzyme Inhib Med Chem 23:391-9 (2008) [PubMed]  Article 
Target
Name:
Glutathione S-transferase E2
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
24847.25
Organism:
Anopheles gambiae (African malaria mosquito)
Description:
Q9GPL8
Residue:
221
Sequence:
MSNLVLYTLHLSPPCRAVELTAKALGLELEQKTINLLTGDHLKPEFVKLNPQHTIPVLDDNGTIITESHAIMIYLVTKYGKDDSLYPKDPVKQARVNSALHFESGVLFARMRFNFERILFFGKSDIPEDRVEYVQKSYELLEDTLVDDFVAGPTMTIADFSCISTISSIMGVVPLEQSKHPRIYAWIDRLKQLPYYEEANGGGGTDLGKFVLAKKEENAKA
  
Inhibitor
Name:
BDBM50186231
Synonyms:
(2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid | CHEMBL456 | ETHACRYNIC ACID | Edecrin | Etacrinic acid | Ethacrynate | Hydromedin | Methylenebutyrylphenoxyacetic acid | [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid | jm5b01461, Compound 72
Type:
Small organic molecule
Emp. Form.:
C13H12Cl2O4
Mol. Mass.:
303.138
SMILES:
CCC(=C)C(=O)c1ccc(OCC(O)=O)c(Cl)c1Cl
Structure:
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