Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM249503
Substrate
n/a
Meas. Tech.
Scintillation Proximity RBP4 Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
14.1±n/a nM
Comments
extracted
Citation
 Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US10072016 Publication Date 9/11/2018 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM249503
Synonyms:
US10072016, Compound 101 | US10407433, Compound 101 | US10913746, Compound 101 | US11649240, Compound 101 | US9434727, 101 | US9777010, Compound 101
Type:
Small organic molecule
Emp. Form.:
C20H19F5N4O3
Mol. Mass.:
458.3819
SMILES:
COC(=O)N1Cc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1
Structure:
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