Target
Transthyretin
Ligand
BDBM249543
Substrate
n/a
Meas. Tech.
Scintillation Proximity RBP4 Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
20.8±n/a nM
Comments
extracted
Citation
 Petrukhin, KCioffi, CJohnson, GAllikmets, RFreeman, EChen, PConlon, MZhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US10072016 Publication Date 9/11/2018 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM249543
Synonyms:
US10072016, Compound 141 | US10407433, Compound 141 | US10913746, Compound 141 | US11649240, Compound 141 | US9434727, 141 | US9777010, Compound 141
Type:
Small organic molecule
Emp. Form.:
C20H22F4N4O3S
Mol. Mass.:
474.472
SMILES:
CS(=O)(=O)N1CCc2[nH]nc(C(=O)N3CCC(CC3)c3cc(F)ccc3C(F)(F)F)c2C1
Structure:
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