Target
Transthyretin
Ligand
BDBM249544
Substrate
n/a
Meas. Tech.
Scintillation Proximity RBP4 Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
23.2±n/a nM
Comments
extracted
Citation
 Petrukhin, KCioffi, CJohnson, GAllikmets, RFreeman, EChen, PConlon, MZhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US10072016 Publication Date 9/11/2018 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM249544
Synonyms:
US10072016, Compound 142 | US10407433, Compound 142 | US10913746, Compound 142 | US11649240, Compound 142 | US9434727, 142 | US9777010, Compound 142
Type:
Small organic molecule
Emp. Form.:
C20H15F4N5O
Mol. Mass.:
417.3596
SMILES:
Fc1ccc(c(c1)C1CCN(CC1)C(=O)c1nnc2ccc(cn12)C#N)C(F)(F)F
Structure:
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