Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Pro-FMRFamide-related neuropeptide FF
Ligand
BDBM86145
Substrate
n/a
Ki
15±n/a nM
Comments
PDSP_2996
Citation
Engström, M; Brandt, A; Wurster, S; Savola, JM; Panula, P Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors. J Pharmacol Exp Ther 305:825-32 (2003) [PubMed] Article More Info.:
Target
Name:
Pro-FMRFamide-related neuropeptide FF
Synonyms:
FMRFamide-related peptides | NPFF_RAT | Npff
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13156.33
Organism:
RAT
Description:
NPFF 0 RAT::Q9WVA9
Residue:
114
Sequence:
MDSKWAAVLLLLLLLRNWGHAEEAGSWGEDQVFAEEDKGPHPSQYAHTPDRIQTPGSLMRVLLQAMERPRRNPAFLFQPQRFGRNAWGPWSKEQLSPQAREFWSLAAPQRFGKK
Inhibitor
Name:
BDBM86145
Synonyms:
L-Met-L-Pro-L-His-L-Serr-L-Phe-L-Ala-L-Asn-L-Leu-L-Pro-L-Leu-L-Arg-L-Phe-NH2 | RFRP-1 | RFamide-related peptide 1
Type:
Small organic molecule
Emp. Form.:
C64H96N18O12S
Mol. Mass.:
1341.625
SMILES:
CSCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |wU:61.65,65.68,42.44,26.27,16.16,12.13,4.4,wD:50.52,73.76,37.40,84.87,(38.04,3.65,;37.72,2.14,;36.25,1.67,;35.93,.16,;34.47,-.32,;33.33,.71,;34.15,-1.82,;32.68,-2.3,;35.29,-2.85,;36.8,-2.53,;37.57,-3.87,;36.54,-5.01,;35.13,-4.39,;33.8,-5.16,;32.47,-4.39,;33.8,-6.7,;32.47,-7.47,;32.47,-9.01,;33.8,-9.78,;33.96,-11.31,;35.47,-11.63,;36.24,-10.29,;35.21,-9.15,;31.13,-6.7,;31.13,-5.16,;29.8,-7.47,;28.46,-6.7,;27.13,-7.47,;27.13,-9.01,;25.8,-9.78,;25.8,-11.32,;27.13,-12.09,;28.46,-11.32,;28.46,-9.78,;28.46,-5.16,;29.8,-4.39,;27.13,-4.39,;27.13,-2.85,;28.46,-2.08,;25.8,-2.08,;24.46,-2.85,;25.8,-.54,;24.46,.23,;23.13,-.54,;21.8,.23,;21.8,1.77,;20.46,-.54,;24.46,1.77,;25.8,2.54,;23.13,2.54,;23.13,4.08,;24.46,4.85,;24.46,6.39,;25.8,7.16,;23.13,7.16,;21.8,4.85,;21.8,6.39,;20.46,4.08,;20.3,2.55,;18.79,2.23,;18.02,3.57,;19.05,4.71,;18.73,6.22,;19.88,7.25,;17.27,6.69,;16.13,5.66,;16.45,4.16,;15.3,3.13,;15.62,1.62,;13.84,3.6,;14.66,6.14,;14.34,7.65,;13.52,5.11,;12.05,5.58,;11.73,7.09,;10.27,7.57,;9.95,9.07,;8.48,9.55,;8.16,11.06,;6.7,11.53,;9.31,12.09,;10.91,4.55,;11.23,3.05,;9.44,5.03,;8.3,4,;6.83,4.47,;5.69,3.44,;4.22,3.92,;3.08,2.89,;3.4,1.38,;4.86,.91,;6.01,1.94,;8.62,2.49,;7.47,1.46,;10.08,2.02,)|
Structure:
