Ki Summary

Reaction Details

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Target

Neuronal acetylcholine receptor subunit alpha-6

Ligand

BDBM86240

Substrate

n/a

66±n/a nM

Comments

PDSP_3077

Citation

Vailati, S; Moretti, M; Longhi, R; Rovati, GE; Clementi, F; Gotti, C Developmental expression of heteromeric nicotinic receptor subtypes in chick retina. Mol Pharmacol 63:1329-37 (2003) [PubMed] Article

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Target

Name:

Neuronal acetylcholine receptor subunit alpha-6

Synonyms:

ACHA6_CHICK | CHRNA6 | Cholinergic, Nicotinic Alpha6

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57501.33

Organism:

Chick

Description:

Cholinergic, Nicotinic Alpha6 0 Chick::P49581

Residue:

494

Sequence:

MHPKRRLCWCLPASGAWAFMLTSLIADTTACESEERLFHKLFSRYNQFIRPVENVSDPVTVHFELAITQLTNVDEVNQIMETNLWLRHIWNDYKLRRDPREYDGIEFVRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLRYDGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAKIDLLIIGSKVDMNEFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVITVFVLNIHYRTPTTHTMPKWVKTVFLSLLPKVLLMQRPLEQEKKNISKKTKKGSAKTSGKSKHSKHKDNKLHKEQRCCHCDKADDLTSTRRSRLSHQSLKWMAEHTEYSPEVKDVINNVQFIAENMKSQNETKEVEDDWKYVAMVIDRVFLWVFIILCVFGTAGLFIQPLIADT

Inhibitor

Name:

BDBM86240

Synonyms:

Alpha-Conotoxin MII | Gly-L-Cys(1)-L-Cys(2)-L-Ser-L-Asn-L-Pro-L-Val-L-Cys(1)-L-His-L-Leu-L-Glu-L-His-L-Ser-L-Asn-L-Leu-L-Cys(2)-NH2

Type:

Small organic molecule

Emp. Form.:

C67H103N23O22S4

Mol. Mass.:

1710.936

SMILES:

CC(C)C[C@@H]1NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CSSC[C@H](NC(=O)CN)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CCC(O)=O)NC1=O)C(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N2

Structure: