Reaction Details
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Neuronal acetylcholine receptor subunit alpha-2
Ligand
BDBM86311
Substrate
n/a
Ki
0.54±n/a nM
Comments
PDSP_609
Citation
Jensen, AA; Mikkelsen, I; Frølund, B; Bräuner-Osborne, H; Falch, E; Krogsgaard-Larsen, P Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors. Mol Pharmacol 64:865-75 (2003) [PubMed] Article More Info.:
Target
Name:
Neuronal acetylcholine receptor subunit alpha-2
Synonyms:
ACHA2_RAT | Acra2 | Cholinergic, Nicotinic Alpha2Beta2 | Cholinergic, Nicotinic Alpha2Beta4 | Chrna2
Type:
Enzyme
Mol. Mass.:
58597.25
Organism:
Rattus norvegicus (Rat)
Description:
P12389
Residue:
511
Sequence:
MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Inhibitor
Name:
BDBM86311
Synonyms:
CAS_485-35-8 | Cytisine | Cytisine-(-) | NSC_22407 | US11667638, Example Cytisine
Type:
Small organic molecule
Emp. Form.:
C11H14N2O
Mol. Mass.:
190.2417
SMILES:
O=c1cccc2C3CNCC(C3)Cn12 |THB:4:5:11:9.8.7|
Structure:
