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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50017452
Substrate
n/a
Ki
1023.29±n/a nM
Comments
PDSP_1240
Citation
 Knight, AR; Misra, A; Quirk, K; Benwell, K; Revell, D; Kennett, G; Bickerdike, M Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol 370:114-23 (2004) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50017452
Synonyms:
2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl | 6'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl(MK-212) | CHEMBL269521 | L-630,571 | MK 212 | MK-212
Type:
Small organic molecule
Emp. Form.:
C8H11ClN4
Mol. Mass.:
198.653
SMILES:
Clc1cncc(n1)N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: