Target
Aurora kinase B
Ligand
BDBM86620
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
3040±0.0 nM
Citation
 Kwiatkowski, NDeng, XWang, JTan, LVilla, FSantaguida, SHuang, HCMitchison, TMusacchio, AGray, N Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol 7:185-96 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM86620
Synonyms:
Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 26
Type:
Small organic molecule
Emp. Form.:
C26H27F3N6O2
Mol. Mass.:
512.5268
SMILES:
CCN1CCN(Cc2ccc(Nc3ncc4N(C)C(=O)c5ccccc5Oc4n3)cc2C(F)(F)F)CC1
Structure:
Search PDB for entries with ligand similarity: