Reaction Details
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Report a problem with these dataTarget
cAMP-dependent protein kinase catalytic subunit beta
Ligand
BDBM86729
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_6132
Citation
Braverman, AS; Tibb, AS; Ruggieri, MR M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder. J Pharmacol Exp Ther 316:869-74 (2006) [PubMed] Article More Info.:
Target
Name:
cAMP-dependent protein kinase catalytic subunit beta
Synonyms:
KAPCB_RAT | PKA | Pkacb | Prkacb | cAMP-dependent protein kinase catalytic subunit beta
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40715.41
Organism:
RAT
Description:
PKA 0 RAT::P68182
Residue:
351
Sequence:
MGNTAIAKKGSEVESVKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF
Inhibitor
Name:
BDBM86729
Synonyms:
(R)-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride | CAS_146986-50-7 | Y-27632
Type:
Small organic molecule
Emp. Form.:
C14H21N3O
Mol. Mass.:
247.336
SMILES:
C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1 |r,wU:6.9,wD:3.2,1.1,(4.6,-3.38,;4.87,-1.86,;6.32,-1.34,;3.69,-.87,;2.92,.46,;1.38,.46,;.61,-.87,;1.38,-2.21,;2.92,-2.21,;-.93,-.87,;-1.7,.46,;-1.7,-2.21,;-3.24,-2.21,;-4.01,-3.54,;-5.55,-3.54,;-6.32,-2.21,;-5.55,-.87,;-4.01,-.87,)|
Structure:
