Reaction Details
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Alpha-1B adrenergic receptor
Ligand
BDBM50033112
Substrate
n/a
Ki
40±n/a nM
Comments
PDSP_181
Citation
Kinsella, GK; Rozas, I; Watson, GW Computational study of antagonist/alpha1A adrenoceptor complexes--observations of conformational variations on the formation of ligand/receptor complexes. J Med Chem 49:501-10 (2006) [PubMed] Article More Info.:
Target
Name:
Alpha-1B adrenergic receptor
Synonyms:
ADRA1B | Adra1b protein | adrenergic Alpha1B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50983.17
Organism:
Mus musculus
Description:
Q05D47
Residue:
462
Sequence:
MNPDLDTGHNTSAPAHWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGGCAYTYRPWTRGGSLERSQSPKDSLDDSGSCMSGSQRTLPSASPSPGYLGLGTQPPVELCASPEWKPGALLSLPEPPGRRGR
Inhibitor
Name:
BDBM50033112
Synonyms:
6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propylamino}-1,3,5-trimethyl-1H-pyrimidine-2,4-dione | CHEMBL420060 | Urapidil-5-methyl
Type:
Small organic molecule
Emp. Form.:
C21H31N5O3
Mol. Mass.:
401.5025
SMILES:
COc1ccccc1N1CCN(CCCNc2c(C)c(=O)n(C)c(=O)n2C)CC1
Structure:
