Reaction Details
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AP-3 complex subunit sigma-2
Ligand
BDBM86757
Substrate
n/a
Ki
123±n/a nM
Comments
PDSP_7627
Citation
Kumar, JS; Prabhakaran, J; Majo, VJ; Milak, MS; Hsiung, SC; Tamir, H; Simpson, NR; Van Heertum, RL; Mann, JJ; Parsey, RV Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates. Eur J Nucl Med Mol Imaging 34:1050-60 (2007) [PubMed] Article More Info.:
Target
Name:
AP-3 complex subunit sigma-2
Synonyms:
AP-3 complex subunit sigma-2 | AP3S2 | AP3S2_BOVIN | Sigma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22029.67
Organism:
BOVINE
Description:
Sigma-2 0 BOVINE::Q1JQA3
Residue:
193
Sequence:
MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEMPRNINIGDLNIKVPNLSQFV
Inhibitor
Name:
BDBM86757
Synonyms:
CAS_0 | NSC_11603174 | [11C]MMP
Type:
Small organic molecule
Emp. Form.:
C19H27N5O3
Mol. Mass.:
373.4494
SMILES:
COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1
Structure:
