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Target
Aurora kinase A
Ligand
BDBM87050
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
pH
7.4±0
Temperature
298.15±0 K
IC50
35±4.1 nM
Kd
49±5.2 nM
Citation
 Martin, MP; Zhu, JY; Lawrence, HR; Pireddu, R; Luo, Y; Alam, R; Ozcan, S; Sebti, SM; Lawrence, NJ; Schönbrunn, E A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A. ACS Chem Biol 7:698-706 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM87050
Synonyms:
Bisanilinopyrimidine inhibitor, 4 | Bisanilinopyrimidine, 6h | US9249124, 31
Type:
Small organic molecule
Emp. Form.:
C18H13F3N4O2
Mol. Mass.:
374.3166
SMILES:
OC(=O)c1ccc(Nc2nccc(Nc3ccccc3C(F)(F)F)n2)cc1
Structure:
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