Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87275
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
7256±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87275
Synonyms:
2-[(2-chloro-1-oxoethyl)-(2,2-dimethoxyethyl)amino]-N-cyclohexyl-2-(2-methylphenyl)acetamide | 2-[(2-chloroacetyl)-(2,2-dimethoxyethyl)amino]-N-cyclohexyl-2-(2-methylphenyl)acetamide | 2-[(2-chloroacetyl)-(2,2-dimethoxyethyl)amino]-N-cyclohexyl-2-(o-tolyl)acetamide | 2-[(chloroacetyl)(2,2-dimethoxyethyl)amino]-N-cyclohexyl-2-(2-methylphenyl)acetamide | 2-[2-chloranylethanoyl(2,2-dimethoxyethyl)amino]-N-cyclohexyl-2-(2-methylphenyl)ethanamide | MLS000583980 | SMR000206966 | cid_12004957
Type:
Small organic molecule
Emp. Form.:
C21H31ClN2O4
Mol. Mass.:
410.935
SMILES:
COC(CN(C(C(=O)NC1CCCCC1)c1ccccc1C)C(=O)CCl)OC
Structure:
Search PDB for entries with ligand similarity: