Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87357
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
5555±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87357
Synonyms:
4-[4-[4-(hydroxymethyl)phenyl]phenyl]-5,6,7-trimethoxy-1-benzopyran-2-one | 4-[4-[4-(hydroxymethyl)phenyl]phenyl]-5,6,7-trimethoxy-chromen-2-one | 4-[4-[4-(hydroxymethyl)phenyl]phenyl]-5,6,7-trimethoxychromen-2-one | 5,6,7-trimethoxy-4-[4-(4-methylolphenyl)phenyl]coumarin | MLS000518082 | SMR000327098 | cid_6540194
Type:
Small organic molecule
Emp. Form.:
C25H22O6
Mol. Mass.:
418.4386
SMILES:
COc1cc2oc(=O)cc(-c3ccc(cc3)-c3ccc(CO)cc3)c2c(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: