Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77727
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
2610±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77727
Synonyms:
(4Z)-4-(4-chlorobenzylidene)-6,7-dimethoxy-isochroman-3-one | (4Z)-4-[(4-chlorophenyl)methylidene]-6,7-dimethoxy-1H-isochromen-3-one | (4Z)-4-[(4-chlorophenyl)methylidene]-6,7-dimethoxy-3,4-dihydro-1H-2-benzopyran-3-one | 4-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-6,7-dimethoxy-isochroman-3-one | MLS000580359 | SMR000220610 | cid_5899355
Type:
Small organic molecule
Emp. Form.:
C18H15ClO4
Mol. Mass.:
330.762
SMILES:
COc1cc2COC(=O)\C(=C/c3ccc(Cl)cc3)c2cc1OC
Structure:
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