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Target
Phosphodiesterase
Ligand
BDBM22926
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.5±0
Temperature
297.15±0 K
IC50
>1.00e+5±n/a nM
Citation
 Wang, H; Kunz, S; Chen, G; Seebeck, T; Wan, Y; Robinson, H; Martinelli, S; Ke, H Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. J Biol Chem 287:11788-97 (2012) [PubMed]  Article 
Target
Name:
Phosphodiesterase
Synonyms:
Cyclic nucleotide specific phosphodiesterase | Phosphodiesterase (TcrPDEC)
Type:
Protein
Mol. Mass.:
103074.59
Organism:
Trypanosoma cruzi
Description:
Q53I59
Residue:
924
Sequence:
MSEDAGLPVPRSQWVERGVSCATCGKRFSLFTAKSNCPCCGKLCCSDCVQAECAIVGGSAPSKVCIDCFSMLQSRRRVEPDEGSSFREFNAASAFPLQTRLLADGRVESGETSRVSPPNDGRVQHVSRANGYSNSLPVLDEYVDDLLRKSELLRMENDVLLNRLREQEAEIHALRLERDRAVARIVPDGGSMAGRSGLPQVSDEIVKELRGELAVAHLRIESVKRELKNALDRAKSSETMVRNLKQGLCNYKEEVVRPLQSREEVEMLPGVNGRRDMISTRRLPPSIVQDTILAVVPPKSCAAIGTDVDLRDWGFDTFEVASRVPSVLQSVAMHVALAWNFFASQEEAQKWAFLVAAVENNYRPNPYHNAIHAADVLQGTFSLVSAAKPLMEHLTPLECKAAAFAALTHDVCHPGRTNAFLAAVQDPVSFKFSGKGTLEQLHTVTAFELLNVTEFDFTSSMDNASFLEFKNIVSHLIGHTDMSLHSETIAKHGAKLSAGGFDCTCKEDRLEALSLLLHAADIGASSRGVAIARKWLVILQEFADQAEDERRRGLPVTPGFDTPSSVEKSQIPFLDFFVIPTFDLLHQLFPSIEEPLHNLRKLRELYAAKAGVTTPFPPPVDYRSREERIRSLEAELAYFRRREEEFHRQLQELRTASENENKSSAAPMTREGALNKQSQLVCRGEGNMNADWADAGGGFRNGKDVRDLQDVSMDHLVSSKTVESDTGDSGPRGRRGSKAETTKAYERKLGEREAALMATARLLENREKRLAVFSEKLAEIAEGLHEERKRLQPMEEFKTPCFSRETELISEESASMDVTHRFSTQWEAEERLARKYRELDELLLIVRAMRMGYAARRNTNLGWKALSATLAEREAAISEAVELSRQRRRHLEEGRGPHPTATHLDRLENATFQLMSAITLLTQC
  
Inhibitor
Name:
BDBM22926
Synonyms:
3-(6-amino-9H-purin-9-yl)nonan-2-ol | EHNA | Erythro-9-(2-hydroxy-3-nonyl)adenine
Type:
Small organic molecule
Emp. Form.:
C14H23N5O
Mol. Mass.:
277.3653
SMILES:
CCCCCCC(C(C)O)n1cnc2c(N)ncnc12
Structure:
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