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Target
Pancreatic alpha-amylase
Ligand
BDBM92366
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
pH
7±0
Temperature
310.15±0 K
Ki
2.04e+5± 7.2e+4 nM
IC50
8.89e+4± 6.0e+3 nM
Citation
 Senger, MR; Gomes, Lda C; Ferreira, SB; Kaiser, CR; Ferreira, VF; Silva, FP Kinetics Studies on the Inhibition Mechanism of Pancreatic α-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity. Chembiochem 13:1584-93 (2012) [PubMed]  Article 
Target
Name:
Pancreatic alpha-amylase
Synonyms:
1,4-alpha-D-glucan glucanohydrolase | AMY2 | AMYP_PIG | Pancreatic α-amylase | Pancreatic α-amylase
Type:
Protein
Mol. Mass.:
57088.07
Organism:
Sus scrofa (Pig)
Description:
P00690
Residue:
511
Sequence:
MKLFLLLSAFGFCWAQYAPQTQSGRTSIVHLFEWRWVDIALECERYLGPKGFGGVQVSPPNENIVVTNPSRPWWERYQPVSYKLCTRSGNENEFRDMVTRCNNVGVRIYVDAVINHMCGSGAAAGTGTTCGSYCNPGNREFPAVPYSAWDFNDGKCKTASGGIESYNDPYQVRDCQLVGLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHMWPGDIKAVLDKLHNLNTNWFPAGSRPFIFQEVIDLGGEAIQSSEYFGNGRVTEFKYGAKLGTVVRKWSGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKVAVGFMLAHPYGFTRVMSSYRWARNFVNGQDVNDWIGPPNNNGVIKEVTINADTTCGNDWVCEHRWRQIRNMVWFRNVVDGQPFANWWANGSNQVAFGRGNRGFIVFNNDDWQLSSTLQTGLPGGTYCDVISGDKVGNSCTGIKVYVSSDGTAQFSISNSAEDPFIAIHAESKL
  
Inhibitor
Name:
BDBM92366
Synonyms:
GPESB14
Type:
Small organic molecule
Emp. Form.:
C13H15N3O4
Mol. Mass.:
277.2759
SMILES:
O[C@@H]1O[C@H](Cn2cc(nn2)-c2ccccc2)[C@H](O)C1O |r|
Structure:
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