Reaction Details Report a problem with these data
Target
Genome polyprotein [1027-1206,R1052K]
Ligand
BDBM92408
Substrate
n/a
Meas. Tech.
Binding Assay
pH
8±0
Ki
1.89±0.06 nM
KOFF
22E-4 s-1
KON
11E5 M-1s-1
Citation
Lemke, CT; Goudreau, N; Zhao, S; Hucke, O; Thibeault, D; Llinás-Brunet, M; White, PW Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335. J Biol Chem 286:11434-43 (2011) [PubMed] Article
More Info.:
Target
Name:
Genome polyprotein [1027-1206,R1052K]
Synonyms:
HCV NS3 Proteinase | NS3-NS4A Protein | POLG_HCVCO
Type:
Enzyme Subunit
Mol. Mass.:
18947.03
Organism:
Hepatitis C virus
Description:
HCV (BK strain) NS3 protein region from amino acid 1 to 180, harboring a C-terminal poly Lys solubilization motif (ASKKKK).
Residue:
180
Sequence:
APITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMR