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Target
Phosphoethanolamine N-methyltransferase 2
Ligand
BDBM50034220
Substrate
n/a
Meas. Tech.
Radiochemical Assay
pH
8±0
Temperature
298.15±0 K
IC50
1.25e+4± 8e+2 nM
Citation
 Lee, SG; Haakenson, W; McCarter, JP; Williams, DJ; Hresko, MC; Jez, JM Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus. J Biol Chem 286:38060-8 (2011) [PubMed]  Article 
Target
Name:
Phosphoethanolamine N-methyltransferase 2
Synonyms:
Phosphoehtnaolamine Methyltransferases 2 (PMT2)
Type:
Enzyme
Mol. Mass.:
49764.45
Organism:
Caenorhabditis elegans
Description:
Q22993
Residue:
437
Sequence:
MSSLSIPRQSLYYVNKVTEGRSVSNVQVVSPCQKQGQTYVTAFTPLTSNVQVHTSLEQLSTIRNADVLIFNNALSQIITNADLLTDFLKNATNATAIGGTVIIREDLKDCSDKRQVARLTDYFDVFRTTDSDGNNTGLDLYTVDQVEHSNYVEQNFLDFIFVFRKKVFAPTTDATITFRDFLDKTQYTNTGIDAYEWMFGVNFISPGGYDENLKIIKRFGDFKPGQTMLDIGVGIGGGARQVADEFGVHVHGIDLSSNMLAIALERLHEEKDSRVKYSITDALVYQFEDNSFDYVFSRDCIQHIPDTEKLFSRIYKALKPGGKVLITMYGKGYGEQSDKFKTYVAQRAYFLKNLKEIADIANKTGFVNVQTENMTPRFKEILLEERGHLEQNEAEFMSKFTQRERDSLISGWTDKLGYIEKDNHNWNFFLAQKPFPK
  
Inhibitor
Name:
BDBM50034220
Synonyms:
2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide | CHEMBL125 | MILTEFOSINE | [2-(Hexadecyloxy-hydroxy-phosphoryloxy)-ethyl]-trimethyl-ammonium | hexadecyl 2-(trimethyl-lambda~5~-azanyl)ethyl hydrogen phosphate | hexadecyl 2-(trimethylammonio)ethyl phosphate | hexadecyloxy-2-trimethylammonioethylphosphorate | hexadecylphosphocholine | hexadecylphosphocholine, miltefosine | n-hexadecylphosphocholine
Type:
Small organic molecule
Emp. Form.:
C21H46NO4P
Mol. Mass.:
407.568
SMILES:
CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C
Structure:
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