Reaction Details Report a problem with these data
Target
Acid phosphatase
Ligand
BDBM92476
Substrate
n/a
Meas. Tech.
Inhibitor Screening Assay
Ki
3.27e+3± 8.5e+2 nM
Citation
 McRae, S; Pagliai, FA; Mohapatra, NP; Gener, A; Mahmou, AS; Gunn, JS; Lorca, GL; Gonzalez, CF Inhibition of AcpA phosphatase activity with ascorbate attenuates Francisella tularensis intramacrophage survival. J Biol Chem 285:5171-7 (2010) [PubMed]  Article 
Target
Name:
Acid phosphatase
Synonyms:
Acid phosphatase (acpA) | Acid phosphatase (acpB) | Acid phosphatase (acpC)
Type:
Enzyme
Mol. Mass.:
22350.38
Organism:
Francisella tularensis
Description:
Q5NIC0
Residue:
194
Sequence:
MTQQQVISYYESTAHENEVELILARAKKIIQAQQSLQGNAIVLDIDETALNHYYSLKLAGFPQGENHTIWNELLSRTDAYPIKATLDFYLYCLTSGLKVFFISARFAQYLESTKQALRNAGYVNFEDVFVFPENIEQYNSKDFKNFKAERRAYIESLGYKILISIGDQSSDLLGGYTLYTLQLPNYLYGENSRF
  
Inhibitor
Name:
BDBM92476
Synonyms:
(+)-5,6-O-Isopropylidene-L-ascorbic acid
Type:
Small organic molecule
Emp. Form.:
C9H12O6
Mol. Mass.:
216.188
SMILES:
CC1(C)OC[C@H](O1)[C@H]1OC(=O)C(=O)C1O
Structure:
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