Reaction Details Report a problem with these data
Target
Beta-adrenergic receptor kinase 1
Ligand
BDBM25770
Substrate
n/a
Meas. Tech.
Inhibition Assay
Kd
7400±0.0 nM
Citation
Strader, CD; Candelore, MR; Hill, WS; Sigal, IS; Dixon, RA Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor. J Biol Chem 264:13572-8 (1989) [PubMed]
More Info.:
Target
Name:
Beta-adrenergic receptor kinase 1
Synonyms:
ADRBK1 | ARBK1_HUMAN | BARK | BARK1 | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein coupled receptor kinase 2 | G-protein coupled receptor kinase 2 (GRK2) | GRK2
Type:
Enzyme
Mol. Mass.:
79581.30
Organism:
Homo sapiens (Human)
Description:
P25098
Residue:
689
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL
Inhibitor
Name:
BDBM25770
Synonyms:
5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol | 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol, 5 | Brethaire | Brethine | Bricanyl | Terbutaline | Terbutaline,(+/-)
Type:
Small organic molecule
Emp. Form.:
C12H19NO3
Mol. Mass.:
225.2842
SMILES:
CC(C)(C)NCC(O)c1cc(O)cc(O)c1