Reaction Details Report a problem with these data
Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50059865
Substrate
n/a
Meas. Tech.
Transferase Assay
Ki
8.3e+2± 8e+1 nM
Citation
 Pompliano, DL; Rands, E; Schaber, MD; Mosser, SD; Anthony, NJ; Gibbs, JB Steady-state kinetic mechanism of Ras farnesyl:protein transferase. Biochemistry 31:3800-7 (1992) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM50059865
Synonyms:
4,8,12-trimethyl-(3E,7E)-3,7,11-tridecatrienylhydroxyphosphorylmethylphosphonic acid anion | CHEMBL103617 | Farnesyl PMP, 2 | N-hydroxyglycine derivative | [Hydroxy-((3E,7E)-4,8,12-trimethyl-trideca-3,7,11-trienyl)-phosphinoylmethyl]-phosphonic acid | [Hydroxy-(4,8,12-trimethyl-trideca-3,7,11-trienyl)-phosphinoyl]-methanephosphonic acid anion | [Hydroxy-(4,8,12-trimethyl-trideca-3,7,11-trienyl)-phosphinoylmethyl]-phosphonate
Type:
Small organic molecule
Emp. Form.:
C17H32O5P2
Mol. Mass.:
378.3805
SMILES:
[#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])-[#6]-[#6]=[#6]P([#8])(=O)[#6]P([#8])([#8])=O |w:14.13|
Structure:
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