Reaction Details Report a problem with these data
Target
Bifunctional aspartokinase/homoserine dehydrogenase 1
Ligand
BDBM92992
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
24000000±5000000 nM
Citation
 Angeles, TS; Hunsley, JR; Viola, RE Reversal of enzyme regiospecificity with alternative substrates for aspartokinase I from Escherichia coli. Biochemistry 31:799-805 (1992) [PubMed]  Article 
Target
Name:
Bifunctional aspartokinase/homoserine dehydrogenase 1
Synonyms:
AK1H_ECOLI | Aspartokinase I | Bifunctional aspartokinase/homoserine dehydrogenase 1 | thrA | thrA1 | thrA2
Type:
Protein
Mol. Mass.:
89109.15
Organism:
Escherichia coli
Description:
P00561
Residue:
820
Sequence:
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDALPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINAALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIPADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRDEDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISFCVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAALARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRYAAEKSRRKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLAREMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
  
Inhibitor
Name:
BDBM92992
Synonyms:
L-glutamate gamma-methyl ester
Type:
Small molecule
Emp. Form.:
C6H10NO4
Mol. Mass.:
160.1484
SMILES:
COC(=O)CC[C@H](N)C([O-])=O
Structure:
Search PDB for entries with ligand similarity: