Target
Egl nine homolog 1
Ligand
BDBM93428
Substrate
n/a
Meas. Tech.
PHD Enzymatic Assay
IC50
103.6±0.0 nM
Citation
 Murray, JKBalan, CAllgeier, AMKasparian, AViswanadhan, VWilde, CAllen, JRYoder, SCBiddlecome, GHungate, RWMiranda, LP Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1a prolyl hydroxylases-1, -2, and -3 with altered selectivity. J Comb Chem 12:676-86 (2010) [PubMed]  Article
Target
Name:
Egl nine homolog 1
Synonyms:
Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM93428
Synonyms:
PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4}
Type:
Small molecule
Emp. Form.:
C37H41N5O8
Mol. Mass.:
683.7501
SMILES:
Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O |r|
Structure:
Search PDB for entries with ligand similarity: