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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM54327
Substrate
n/a
IC50
20000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM54327
Synonyms:
2-[(6-bromanylquinazolin-4-yl)amino]-4-nitro-phenol;hydrochloride | 2-[(6-bromo-4-quinazolinyl)amino]-4-nitrophenol hydrochloride | 2-[(6-bromo-4-quinazolinyl)amino]-4-nitrophenol;hydrochloride | 2-[(6-bromoquinazolin-4-yl)amino]-4-nitro-phenol;hydrochloride | 2-[(6-bromoquinazolin-4-yl)amino]-4-nitrophenol;hydrochloride | MLS000690693 | SMR000301111 | cid_5711520
Type:
Small organic molecule
Emp. Form.:
C14H9BrN4O3
Mol. Mass.:
361.15
SMILES:
Oc1ccc(cc1Nc1ncnc2ccc(Br)cc12)[N+]([O-])=O
Structure:
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