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Target
Tyrosine-protein kinase transforming protein Src
Ligand
BDBM4028
Substrate
poly(E,Y)
Meas. Tech.
Kinase Inhibition Assay
IC50
5800±n/a nM
Citation
 Rewcastle, GW; Palmer, BD; Dobrusin, EM; Fry, DW; Kraker, AJ; Denny, WA Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide). J Med Chem 37:2033-42 (1994) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase transforming protein Src
Synonyms:
P60-Src | SRC_AVISR | V-SRC | pp60v-src
Type:
Enzyme
Mol. Mass.:
58884.32
Organism:
Avian sarcoma virus
Description:
P00525
Residue:
526
Sequence:
MGSSKSKPKDPSQRRCSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPECPESLHDLMCQCWRRDPEERPTFEYLQAQLLPACVLEVAE
  
Inhibitor
Name:
BDBM4028
Synonyms:
1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-5-(trifluoromethyl)-1H-indol-2-yl]disulfanyl}-N-phenyl-5-(trifluoromethyl)-1H-indole-3-carboxamide | CHEMBL61278 | dithiobis(1H-indole-3-carboxamide) deriv. 10m
Type:
Small organic molecule
Emp. Form.:
C34H24F6N4O2S2
Mol. Mass.:
698.7
SMILES:
Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(ccc3n2C)C(F)(F)F)c(C(=O)Nc2ccccc2)c2cc(ccc12)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
poly(E,Y)
Synonyms:
n/a
Type:
Random Polymer
Mol. Mass.:
358.43
Organism:
n/a
Description:
poly[(glu)4(tyr)l]. 5 uM ATP containing 0.2 uCi 32P labeled ATP as co-substrate.
Residue:
3
Sequence:
NA