Reaction Details Report a problem with these data
Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM41086
Substrate
n/a
IC50
17913±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM41086
Synonyms:
MLS000582064 | N-[3-chloranyl-4-(2-oxidanylidenechromen-3-yl)phenyl]pyridine-3-carboxamide | N-[3-chloro-4-(2-ketochromen-3-yl)phenyl]nicotinamide | N-[3-chloro-4-(2-oxo-1-benzopyran-3-yl)phenyl]-3-pyridinecarboxamide | N-[3-chloro-4-(2-oxo-2H-chromen-3-yl)phenyl]nicotinamide | N-[3-chloro-4-(2-oxochromen-3-yl)phenyl]pyridine-3-carboxamide | SMR000201281 | cid_1252084
Type:
Small organic molecule
Emp. Form.:
C21H13ClN2O3
Mol. Mass.:
376.793
SMILES:
Clc1cc(NC(=O)c2cccnc2)ccc1-c1cc2ccccc2oc1=O
Structure:
Search PDB for entries with ligand similarity: