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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95204
Substrate
n/a
IC50
31284±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95204
Synonyms:
4-[(2-keto-4-methyl-chromen-7-yl)oxymethyl]benzoic acid [2-[2-(difluoromethoxy)anilino]-2-keto-ethyl] ester | 4-[(4-methyl-2-oxo-1-benzopyran-7-yl)oxymethyl]benzoic acid [2-[2-(difluoromethoxy)anilino]-2-oxoethyl] ester | MLS000375413 | SMR000254667 | [2-[2-(difluoromethoxy)anilino]-2-oxoethyl] 4-[(4-methyl-2-oxochromen-7-yl)oxymethyl]benzoate | [2-[[2-[bis(fluoranyl)methoxy]phenyl]amino]-2-oxidanylidene-ethyl] 4-[(4-methyl-2-oxidanylidene-chromen-7-yl)oxymethyl]benzoate | cid_2448970
Type:
Small organic molecule
Emp. Form.:
C27H21F2NO7
Mol. Mass.:
509.4549
SMILES:
Cc1cc(=O)oc2cc(OCc3ccc(cc3)C(=O)OCC(=O)Nc3ccccc3OC(F)F)ccc12
Structure:
Search PDB for entries with ligand similarity: