Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM95919
Substrate
n/a
EC50
>12500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM95919
Synonyms:
2-(4-methoxyphenyl)-5-(4-methylphenyl)-2,3-dihydro-1,3,4-thiadiazole | 2-(4-methoxyphenyl)-5-(p-tolyl)-2,3-dihydro-1,3,4-thiadiazole | MLS001198724 | SMR000558798 | cid_2871198
Type:
Small organic molecule
Emp. Form.:
C16H16N2OS
Mol. Mass.:
284.376
SMILES:
COc1ccc(cc1)C1=NNC(S1)c1ccc(C)cc1 |t:9|
Structure:
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