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Target
Dual specificity mitogen-activated protein kinase kinase 1 [2-31,52-393,S218E,S222D]
Ligand
BDBM1714
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.3±n/a
Temperature
298.15±n/a K
IC50
<5±n/a nM
Comments
extracted
Citation
 Dong, Q; Kaldor, SW MAPK/ERK kinase inhibitors US Patent  US8470837 Publication Date 6/25/2013 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 1 [2-31,52-393,S218E,S222D]
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 | MEK1 | MP2K1_HUMAN | PRKMK1
Type:
Protein
Mol. Mass.:
40898.07
Organism:
Homo sapiens (Human)
Description:
Q02750[2-31,52-393,S218E,S222D]
Residue:
372
Sequence:
PKKKPTPIQLNPAPDGSAVNGTSSAETNLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANDFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
  
Inhibitor
Name:
BDBM1714
Synonyms:
CHEMBL1684071 | US8470837, 13
Type:
n/a
Emp. Form.:
C18H18FIN4O4
Mol. Mass.:
500.2628
SMILES:
Cc1c(Nc2ccc(I)cc2F)c2c(ncn(C[C@H](O)CO)c2=O)n(C)c1=O |r|
Structure:
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