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Target
Macrophage colony-stimulating factor 1
Ligand
BDBM97726
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Competition Immunoassay
pH
7.5±0
IC50
3±n/a nM
Citation
 Illig, CR; Ballentine, SK; Chen, J; DesJarlais, RL; Meegalla, SK; Wall, M; Wilson, K Inhibitors of c-fms kinase US Patent  US8481564 Publication Date 7/9/2013 
Target
Name:
Macrophage colony-stimulating factor 1
Synonyms:
CSF1_MOUSE | Csf1 | Csfm | Macrophage colony-stimulating factor 1 (CSF-1)
Type:
Protein
Mol. Mass.:
60631.84
Organism:
Mus musculus (Mouse)
Description:
P07141
Residue:
552
Sequence:
MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSSRDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELPLRIEDPGSAKQRPPRSTCQTLESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDILESSLGTNWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQAETDRPRALSASPFPKSTEDQKPVDITDRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSNSATPVAQLLLPKSHSWGIVLPLGELEGKRSTRDRRSPAELEGGSASEGAARPVARFNSIPLTDTGHVEQHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSHRDPQTLDSSVGRPEDSSLTQDEDRQVELPV
  
Inhibitor
Name:
BDBM97726
Synonyms:
US8481564, 4
Type:
Small organic molecule
Emp. Form.:
C21H22N6O2
Mol. Mass.:
390.4384
SMILES:
O=C(Nc1ccc(cc1C1=CCCCC1)C1CNC(=O)NC1)c1nc(c[nH]1)C#N |t:10|
Structure:
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