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Target
Cathepsin K
Ligand
BDBM100296
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
Ki
0.45±0.0 nM
Citation
 Quibell, M; Watts, JP Piperazine compounds US Patent  US8501744 Publication Date 8/6/2013 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM100296
Synonyms:
US8501744, 17
Type:
Small organic molecule
Emp. Form.:
C28H35F2N5O4S
Mol. Mass.:
575.67
SMILES:
CC(C)C[C@H](NC(=O)c1ccc(cc1)-c1csc(n1)N1CCN(C)CC1)C(=O)N1C[C@@H](C(F)F)[C@H]2OCC(=O)[C@@H]12 |r|
Structure:
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